Webináře Thermo Fisher Scientific říjen - prosinec 2026
HPLC Ask the Experts – Practical Tips & Tricks
What you will learn:
- Troubleshooting made easier: Learn how to systematically identify, isolate, and resolve common HPLC/UHPLC issues
- Tips, tricks & best practices: Gain practical recommendations for reliable results and optimized chromatographic workflows
- Expert knowledge first-hand: Get answers and practical solutions to your HPLC questions submitted in advance
Learn how parallel workflows can complete 320 chromatographic runs in 48 hours, cut instrument time by 50%, reduce manual handling, and generate comprehensive data for method selection. The session will also examine sequence-dependent strand separation and elution behavior that can influence analytical performance and optimization.
Key learnings:
- How to design a comprehensive denaturing IP-RPLC-UV scouting strategy for siRNA purity and impurity assessment.
- How a dual-channel UHPLC workflow can increase throughput while reducing instrument time and manual intervention.
- How to compare six ion-pairing reagents and four stationary phases for sense- and antisense-strand separation.
- How retention-time differences, peak shape, and strand-area trends can help prioritize conditions for further optimization.
- Why ion-pairing reagent performance and strand elution order can be sequence dependent—and why column chemistry may have a secondary influence.
Whole-tissue, parallel mapping of 10,000 proteins and 30,000 phosphosites by integrating MASP with OptiSpray/Orbitrap Astral
Key learnings:
- Understanding the fundamentals of Phos-MASP and its significance in spatial phosphoproteomics
- Best practices for implementing Phos-MASP in research
- How Phos-MASP enables parallel profiling of both the proteome and phosphoproteome from the same tissue
- Insights into the robust, reproducible separation of Thermo Scientific OptiSpray ion source and the ultra-sensitive quantification capabilities of the Thermo Scientific Orbitrap Astral MS
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Real-world applications of Phos-MASP in mapping disease-specific intra-brain distributions in Alzheimer's Disease models
Overcome separation and MS challenges in complex biotherapeutic analyses: Practical approaches to impurity characterization, adsorption, adducts, and PTMs
Key learnings
- Understand how reversed-phase chromatography supports the analysis of diverse biotherapeutic modalities.
- Explore the benefits of a bioinert LC platform for sensitive biotherapeutic workflows.
- Learn how design of experiments can optimize ion-pairing conditions for oligonucleotide LC-MS analysis.
- See how Orbitrap mass spectrometry enables multi-level ADC characterization.
- Discover how intact, subunit, and bottom-up workflows support DAR determination and PTM profiling.
Meet the scientists leveraging the latest advances in mass spectrometry to make tomorrow’s discovery. The Groundbreakers Series brings together some of the most innovative researchers across proteomics, metabolomics, structural biology, and biopharma to share how the latest innovations in mass spectrometry are moving their work forward.
- Tuesday, October 20, 2026 - Advancing Oligonucleotide Bioanalysis with High-Resolution Mass Spectrometry
- Wednesday, October 21, 2026 – Ask the Expert: Explore the New Thermo Scientific™ Orbitrap™ Tribrid™ Apex Mass Spectrometer
- Wednesday, October 28, 2026 – Enhancing access to the glycoproteome through advances to the Thermo Scientific™ Orbitrap™ Tribrid™ mass spectrometer platform
- Thursday, October 29, 2026 – Metabolomics without compromises: Extending dynamic range and enabling simultaneous quantitation and discovery in metabolomics using eDR
- Thursday, November 05, 2026 – Multi-LC-MS Platform Plasma Steroidomic and Lipidomic Profile Analyses in BRCA1/2 Mutation Carriers and Breast Cancer Risk: A Retrospective Komen Tissue Bank Study
- Tuesday, November 17, 2026 - Advancing Impurity and Degradation Product Identification in Synthetic Peptides
- Tuesday, November 17, 2026 - Advancing Impurity and Degradation Product Identification in Synthetic Peptides
- Thursday, November 19, 2026 - Breakthrough Technology for Proteoform Profiling and Deep Proteoform Sequencing for Compositional and Structural Proteomics
- Tuesday, December 08, 2026 - Advancing the characterization of mono- and multi-specific antibodies at the intact and subunit levels using IR photon-assisted dissociation methods




