On-Demand Webinar: Direct Analysis of Heterogeneous Biotherapeutics

This webinar presents a new approach to glycoform fingerprinting that uses proton-transfer charge-reduction with gas-phase fractionation to analyze intact glycoproteins on the Thermo Scientific Orbitrap Ascend MS platform. The method provides a detailed landscape of the intact molecular weights present in biotherapeutic protein preparations in a single experiment and offers insights into glycoform composition when coupled with a suitable bioinformatic strategy.

In addition, we highlight the application of charge detection native mass spectrometry (Thermo Scientific Direct Mass Technology mode available on the Thermo Scientific Q Exactive UHMR MS) towards the elucidation of masses and aggregation of heterogeneous glycosylated biotherapeutics.

About the presenter:

• Wendy Sandoval , Director, Translational Mass Spectrometry, Genentech
  
  Wendy Sandoval and her team focus on analytical methods to characterize new biotherapeutic modalities including native and top-down mass spectrometry, resolving protein interactions, and lipidomics to support early research and clinical projects. Wendy has co-authored over 100 manuscripts and two books.